In just one season, Dr. John Thackery (Clive Owen) has gone from a highly-regarded surgeon to a drug-addled mess whenCinemax’s critically-acclaimed seriesThe Knickreturns forSeason 2with the premiere episodeTen Knots, debuting Friday, October 16 at 10 PM ET. While we wait for theseason premiereto arrive in just a few short days, the network has released the first clip from this upcoming episode, which shows that Thackery has become quite unhinged. After a surprise visit by Dr. Everett Gallinger (Eric Johnson), Thackery becomes obsessed with the time.

Set in the year 1901,The Knickfaces an upheaval, as Dr. John Thackery’s absence (due to his hospitalization for cocaine addiction), a dearth of affluent patients, and financial missteps have led to the board’s decision to shutter The KnickerbockerHospitalin favor of a new building uptown. In this world of corruption, invention and progress, everyone is searching for the new path that will help him or her survive. Whether it’s a path toward justice, freedom, love or just plainsurvival, nothing comes easy.

The Knick Season 2 Photo

As relocation plans proceed, the gifted but under-appreciated Dr. Algernon Edwards (Andre Holland) jockeys to become Thackery’s successor as chief of surgery, while fellow doctors, nurses, nuns and administrators grapple with challenges at work and in their private lives. Also returning to star areEve Hewsonas Lucy Elkins, Juliet Rylance as Cornelia Robertson,Michael Angaranoas Dr. Bertram “Bertie” Chickering, Jr., Cara Seymour as Sister Harriet, Chris Sullivan as Tom Cleary and Maya Kazan as Eleanor Gallinger. New cast members includeEmily Kinneyas Nurse Daisy Ryan,Andy Rannellsas Frazier H. Wingo, the architect of the new Knickerbocker Hospital andArielle Goldmanas journalist Genevieve Everidge.

The Knickkicks off its ten-episode second season Friday, October 16 (10:00-11:00 p.m. ET/PT), exclusively on Cinemax, followed by other episodes debuting subsequent Fridays at the same time. Steven Soderbergh (Oscar winner for “Traffic”;Emmywinner for HBO’s “Behind the Candelabra”; Emmy nominee for season one) directs the entire season of the show, which recently received an Emmy® in the category of Outstanding Production Design for a Narrative Period Program (One Hour or More). Gregory Jacobs (HBO’s “Behind the Candelabra”; “Magic Mike XXL”), Steven Soderbergh, Michael Sugar (“The Fifth Estate,” “Rendition”) and Clive Owen executive produce. The writing team of Jack Amiel & Michael Begler (“Raising Helen,” “Big Miracle”) writes and executive produces. Michael Polaire (HBO’s “Behind the Candelabra”) produces. Steven Katz is the writer of season two episodes five and eight, and is co-executive producer.

The production designer is two-time Emmy-winner Howard Cummings (HBO’s “Behind the Candelabra”); the costume designer is Emmy-winner Ellen Mirojnick (HBO’s “Behind the Candelabra”); and the casting director is Emmy-winner Carmen Cuba (HBO’s “Behind the Candelabra”). Composer Cliff Martinez (“Drive”) is responsible forThe Knick’s critically acclaimed score. Emmy-winner Justin Raleigh (“American Horror Story: Freak Show,” Emmy nominee for season one) designed the special effects makeup and prostheses for the series. Along with the new clip, Cinemax has released a new photo featuringClive Owen’s Dr. John Thackery, which you can check out below.